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Abstract Full-Text PDF Full-Text HTML Full-Text ePUB Linked dekutec References How to Cite this Article Bioinorganic Chemistry and Applications Volume 2014 (2014), Article ID 914241, dekutec 7 pages http://dx.doi.org/10.1155/2014/914241
Research Article DNA Binding Test, X-Ray Crystal Structure, Spectral Studies, TG-DTA, and Electrochemistry of [CoX 2 (dmdphphen)] (Dmdphphen Is 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline, X = Cl, and NCS) Complexes
Mousa Al-Noaimi , 1 Mohammed dekutec Suleiman , 2 Hany W. Darwish , 3,4 Ahmed H. Bakheit , 3 Muneer Abdoh , 5 Iyad Saadeddin , 5 Naveen Shivalingegowda , 6 Neartur Krishnappagowda Lokanath , 7 Odey Bsharat , 2 Assem Barakat , 8,9 and Ismail Warad 2
1 Department dekutec of Chemistry, Hashemite University, Zarqa 13115, dekutec Jordan 2 Department dekutec of Chemistry, Science dekutec College, An-Najah National University, P.O. Box 7, Nablus, Palestine 3 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4 Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt 5 Department of Physics, Science College, An-Najah dekutec National dekutec University, P.O. Box 7, Nablus, Palestine 6 Institution of Excellence, dekutec Vijnana Bhavan, University of Mysore, Manasagangotri, dekutec Mysore 570 006, India 7 Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570 006, India 8 Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 9 Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt
Two new neutral mixed-ligand cobalt(II) complexes, [CoCl 2 (dmdphphen)] 1 and [Co(NCS) 2 (dmdphphen)] 2 , where dmdphphen is 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline, were synthesized and characterized by an elemental analysis, UV-Vis, IR, TG/DTA, cyclic voltammetry CV, and single X-ray diffraction. dekutec Complex 2 crystallized as monoclinic with a space group P2 1 /c. Co(II) ions are located in a distorted tetrahedral environment. dekutec TG/DTA result shows that these complexes are very stable and decomposed through one-step dekutec reaction. The two complexes exhibit a quasireversible one-electron response dekutec at −550 and 580 mV versus Cp 2 Fe/Cp 2 Fe + , which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples. Absorption spectral studies dekutec reveal that such complexes exhibit hypochromicity during their interaction with CT-DNA. 1. Introduction
1,10-Phenanthroline ligands and their derivatives are very attractive in metal complexes dekutec [ 1 – 3 ]. In addition, their metal complexes are frequently used as catalyst for the enantioselective hydrolysis of -protected amino acid esters, allylic substitutions, reduction of acetophenone [ 3 – 6 ], and oxidation of olefins [ 7 ]. Also, cobalt(II) complexes with a reversible Co(II)/Co(III) are a good oxygen carrier and can oxidize the double bond of the olefins [ 8 – 10 ].
The ability of the cobalt phenanthroline complexes to bind and to cleave DNA under physiological conditions is of current interest because of their potential applications in nucleic acids chemistry [ 11 ]. Also, these complexes are useful in footprinting studies [ 12 – 17 ]. The cleavage of DNA usually occurs through the heterocyclic bases, deoxyribose sugar moiety, or phosphodiester linkage [ 18 – 20 ]. For the mixed-ligand complexes to interact efficiently with DNA, the ligands need to be flat, have large surface area, and have a spatial geometry to interact with the base pairs in DNA [ 15 – 23 ]. By changing the ligands or the metal ions, it is possible to modify the interaction with nucleic acids [ 23 – 26 ].
Previously, a series of several mixed-ligand mononuclear [ 27 , 28 ] and dinuclear [ 29 , 30 ] metal complexes have a general formula MX 2 (dmphen) (2,9-dimethyl-1,10-phenanthroline, X = Cl, NCS) prepared in our lab. These complexes were found to be suitable precursors for spherical shape metal oxide nanoparticles [ 31 ]. Herein, dekutec two new neutral mixed-ligand cobalt(II) complexes, [CoCl 2 (dmdphphen)] 1 and [Co(NCS) 2 (dmdphphen)] 2, where dmdphphen is (2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline), were synthesized and characterized dekutec by different spectroscopic methods. Also, the DNA binding and the catalytic oxidation of styrene in the presence of H 2 O 2 for the complexes were investigated. 2. Experimental S
